| 학회 | 한국고분자학회 |
| 학술대회 | 2004년 가을 (10/08 ~ 10/09, 경북대학교) |
| 권호 | 29권 2호, p.358 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Synthesis of Gd-DTPA-polysuccinimide : the micelle-form gadolinuim complex as a potential MRI contrast agent |
| 초록 | Diethylenetriaminepentaacetic acid (DTPA) is a very efficient chelating agent for the complexation of the gadolinium (Gd) ion. This corresponding comlex, due to its high in vivo stability, has been safely used as contrast agent in MRI and MRA over the past decade1. Also polysuccinimide (PSI) is physico-chemical characteristics for development of macromolecular prodrugs, due to biocompatibility, biodegradability, easy synthesis, low cost and easy functionalization2,3. In this work, we deal with the synthesis of PSI having various functional groups such as poly(ethylene glycol) (PEG), Hexadecylamine (C16) and Gd-DTPA via ring opening of PSI. And the formation of nanoparticle micelle as drug carrier were also examined. PSI was synthesized by polycondensation polymerization of aspartic acid. Functionalization of PSI was carried out by introduction of PEG, C16 and Gd-DTPA into PSI. All materials were characterized by 1H-NMR, EA and EDS. Micelle size was measured by ELS and AFM. Fig. 1 and 2 showed micelle size and shape. The size of functionalized PSI had an average size of 250 nm ～ 300 nm. And the shape was spherical. In conclusions, we prepared PSI functionalized with PEG, C16 and Gd-DTPA. Fig. 1 Micelle size of PSI-PEG-C16- DTPA-Gd : 308.5 nm. Fig. 2 Micelle shape of PSI-PEG- C16-DTPA-Gd. Acknowledgement : This work was supported by KMOCIE(10011394). 참고문헌 1. L. Lattuada and G. Lux, Tetrahedro. Letters., 44, 3893 (2003). 2. T. Ouchi, M. Shiratani, M. Jinno, M. Hirao and Y. Ohya, Macromol. Chem., 14, 825 (1993). 3. T. Hayashi and M. Iwatsuki, Biopolymers, 29, 549 (1990). |
| 저자 | 임낙현1, 이하영1, 정상영1, 김문석1, 강길선2, 이해방1, 조선행1 |
| 소속 | 1한국화학(연), 2전북대 |
| 키워드 | polysuccinimide; gadolinium; DTPA; MRI; contrast; micelle |
