| 학회 |
한국고분자학회 |
| 학술대회 |
2009년 봄 (04/09 ~ 04/10, 대전컨벤션센터) |
| 권호 |
34권 1호 |
| 발표분야 |
고분자 합성 |
| 제목 |
Preparation of theragnostic agent for multifunctional drug delivery system |
| 초록 |
The poly amino acid, PHEA(Poly-hydroxyethylaspatamide) is known as a useful biomaterial with appropriate structural modification. In this study, we synthesized PHEA-mPEG-C16 by condensation polymerization and synthesized with iron oxide by coprecipitation method for using a contrast agent. It called PSI-USPIO, we loaded hydrophobic drug such as doxorubicin into the PSI-USPIO. Finally, we were prepared mutifunctional drug deliver carrier which combined system of imaging and therapy whole in one and called PSI-USPIO-DOX. We were characterized physical property by ELS, TEM, ICP analysis. The intracellular uptake was confirmed against B16F10 murine melanoma cell by fluorescence activated cell sorter(FACS) and conforcal laser microscopy. The anticancer activity was confirmed in mice bearing of B16F10 murine melanoma model as growth pattern of the tumor and observed in rabbits bearing of VX2 hepatoma model by 3.0T clinical magnetic resonance image (MRI) system. |
| 저자 |
김효정1, 김병진1, 최연웅2, 정상영3, 곽병국4, 육순홍5, 정서영6, 조선행1
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| 소속 |
1한국화학(연), 2한국유나이티드제약, 3한국콜마, 4중앙대, 5한남대, 6경희대 |
| 키워드 |
Mutifuctional drug delivery carrier; PSI-USPIO-Dox; contrast agent
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| E-Mail |
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