| 초록 |
Autosomal dominant polycystic kidney disease (ADPKD) is the most common monogenic disease that affects at least one out of thousand people. It develops numerous and enlarging fluid-filled cysts that cause both increase of kidney volume and loss of kidney function, leading to end-stage renal disease (ESRD). Although advances in ADPKD studies have identified multiple players in disease development, pharmaceutics and clinical trials to cope with the progression of the disease is not without limitation, leaving renal transplants as ultimate solution. In this study, we aim to investigate and assess the effect of combinational treatment of dietary supplements, such as hydroxycitrate, chromax chromium picolinate and others on cyst growth. For in vitro treatment, we used Madin-Darby canine kidney (MDCK) cell derived cyst model. By the use of already approved dietary supplements to suppress cystic growth, we expect this study to render a readily available method to prolong cyst developments. |
