| 학회 |
한국공업화학회 |
| 학술대회 |
2018년 가을 (10/31 ~ 11/02, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 |
22권 2호 |
| 발표분야 |
생체재료_포스터 |
| 제목 |
Redox-responsive delivery of nanophotosensitizer based on chlorin-conjugated methoxy poly(ethylene glycol)-g-chitosan through disulfide linkage |
| 초록 |
In this study, we synthesized methoxy poly(ethylene glycol)-g-chitosan (ChitoPEG) and Ce6 was conjugated with ChitoPEG copolymer using disulfide linkage (Abbreviated as ChitoPEGssCe6). Since disulfide bond can be reduced by glutathione (GSH) and intracellular GSH level is significantly higher in cancer cells and extracellular fluids, disulfide bond linkage induces cancer-specific delivery of photosensitizer. ChitoPEGssCe6 nanophotosensitizer shows small particle size less than 100nm and spherical shapes. In fluorescence excitation study, ChitoPEGssCe6 nanophotosensitizer showed ground state in the aqueous solution but GSH addition induced Ce6 liberation from nanophotosensitizer and activated. These results indicated that ChitoPEGssCe6 nanophotosensitizer has redox-responsiveness. |
| 저자 |
정경원1, 홍웅길1, 차병열2, 안준혁1, 정영일3, 나재운1
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| 소속 |
1순천대, 2김해 바이오메디칼 연구센터, 3양산 부산대 |
| 키워드 |
ROS; Chitosan; Photodynamic therapy; chlorin e6; glutathione
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| E-Mail |
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