| 학회 |
한국고분자학회 |
| 학술대회 |
2020년 가을 (10/05 ~ 10/08, 부산컨벤션센터(BEXCO)) |
| 권호 |
45권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Ultrasound-Mediated Enhanced Drug Delivery and Targeted Imaging by Using Microbubble-Self-Aggregate Complex |
| 초록 |
Microbubbles play a role not only ultrasound contrast agent for use molecular imaging but ultrasound mediated drug delivery carrier. Microbubble able to deliver the drug by conjugation of drug delivery carriers like liposome or nanoparticles. Under the intensive ultrasound, microbubble undergoes collapse and release conjugated nanoparticles. Destruction of microbubble produces strong mechanical stress called microjets, it can partially damage blood vessel so a selective increase of permeability is possible. By using this technique, selective expose of ultrasound to target area make a targeted drug delivery. In this study, hydrophobic drug loaded self-assembled nanostructure was chemically conjugated to microbubble. Microbubble and self-assembled nanostructure size distribution were analyzed with dynamic laser scattering (DLS), conjugation ration of microbubble and micelle were examined by UV-vis spectroscopy. |
| 저자 |
정인재1, 문형원2, 이학종3, 안철희4
|
| 소속 |
1Research Institute of Advanced Materials (RIAM), 2Department of Materials Science and Engineering, 3College of Engineering, 4Seoul National Univ. |
| 키워드 |
Ultrasound; Microbubble; Self-aggregate; Drug delivery; Targeted imaging
|
| E-Mail |
|
