| 학회 |
한국고분자학회 |
| 학술대회 |
2014년 봄 (04/10 ~ 04/11, 대전 컨벤션센터) |
| 권호 |
39권 1호 |
| 발표분야 |
대학원생 구두발표(영어발표, 발표10분) |
| 제목 |
Graphene Oxide Induced Gold Nanoparticle Clusters as Surface Enhanced Raman Scattering Nanoprobes for Biosensing |
| 초록 |
Surface-enhanced Raman scattering (SERS) spectroscopy has great potential for fast trace detection without any labeling. We previously reported that gold nanoparticle clusters (GNPCs) were formed by nano-sized graphene oxides (NGOs) to develop a new class of SERS nanoprobes for highly sensitive biosensing. In this study, sandwich-type immunocomplexes consisting of the NGO-GNPCs as SERS nanoprobes and magnetic beads (MBs) as magnetic field-based separation tools were developed for detection of Immunoglubulin G (IgG) as antigens. Anti-IgG polyclonal antibodies were chemically conjugated with the NGO-GNPCs while anti-IgG monoclonal antibodies being conjugated with the MBs by using their residual -COOH groups. The NGO-GNPCs-antigen-MBs complexes were formed in the presence of IgG and there was a linear correlation between Raman intensity and IgG concentration. In conclusion, the NGO-GNPCs are useful as SERS nanoprobes for SERS-based biosensing applications. |
| 저자 |
Ahmed Ali1, 장홍덕2, 정찬우3, 주재범1, 임동우2
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| 소속 |
1Department of Bionanotechnology, 2Hanyang Univ., 3ERICA Campus |
| 키워드 |
Graphene Oxide; Gold nanoparticle clusters; Surface Enhanced Raman Scattering; Nanoprobes; Biosensing
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| E-Mail |
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