| 학회 |
한국고분자학회 |
| 학술대회 |
2018년 봄 (04/04 ~ 04/06, 대전컨벤션센터) |
| 권호 |
43권 1호 |
| 발표분야 |
DNA/Protein/Peptide 거대분자체 조립: 원리 및 응용 |
| 제목 |
DNA walkers via strand displacement on a microparticle surface |
| 초록 |
Molecular machines have previously been designed that are propelled by DNAzymes, protein enzymes and strand displacement. These engineered machines typically move along precisely defined one- and two-dimensional tracks. Here, we report two different DNA walker systems (bipedal and unipedal) that use hybridization to drive walking on DNA-coated microparticle surfaces. Through purely DNA:DNA hybridization reactions, the nanoscale movements of the walker can lead to the generation of a single-stranded product and the subsequent immobilization of fluorescent labels on the microparticle surface. These autonomous walkers may be of use in analytical and diagnostic applications, similar to how strand exchange reactions in solution have been used for transducing and quantifying signals from isothermal molecular amplification assays. |
| 저자 |
정철희 |
| 소속 |
고려대 |
| 키워드 |
strand displacement; DNA walker; microparticle
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| E-Mail |
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