| 학회 |
한국고분자학회 |
| 학술대회 |
2009년 가을 (10/08 ~ 10/09, 광주과학기술원 오룡관) |
| 권호 |
34권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Metalic nanorods for bi-functional drug delivery system |
| 초록 |
Bi-segmented nanorods were fabricated by electro-deposition. Length of each segment was controlled by changing the amount of coulombs applied during the deposition. A diameter of the fabricated segment was 200nm and the length of total segment was ranged from 1000nm to 2500nm. Thiol-modified Pluronic was conjugated with the gold segment to encapsulate excessive amounts of doxorubicin according to temperature changes. Carboxyl group of folate was attached on the nickel segment to confer an active targeting moiety to the nanorod toward cancer cells. Doxorubicin was maximally encapsulated around the modified nanorods at 37°C and a full extent of doxorubicin release was observed at 4°C. Further studies are required determine amounts of drug loading according to gold segment length, targeting effects of folate. In addition, pharmacodynamics of doxorubicin-encapsulated nanorods should be also optimized to employ nanorods as multifunctional anti-cancer drug carriers. |
| 저자 |
박신영1, 최지숙1, 김혜성1, 정현아1, 유혁상1, 김지훈2
|
| 소속 |
1강원대, 2포항공과대 |
| 키워드 |
nanorod; anti-cancer; DDS
|
| E-Mail |
|
