| 학회 |
한국고분자학회 |
| 학술대회 |
2009년 가을 (10/08 ~ 10/09, 광주과학기술원 오룡관) |
| 권호 |
34권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Magnetite nanoparticles in microsphere for intestinal delivery |
| 초록 |
Magnetite nanoparticles are degraded in acidic solutions, therefore cannot be employed for peroral delivery. Amphiphilic polymer-stabilized magnetite nanoparticles were prepared for efficient encapsulation within pH-sensitive microspheres. A di-block copolymer composed of PCL and methoxy PEG (mPEG-PCL) was dissolved in dichloromethane and FeCl₂.FeCl₃ in aqueous phase was added to organic phase. Ammonium hydroxide solution was added to mixture with the block copolymer. Eudragit L100-55 and the magnetite nano-aggregates in a methanol/acetone mixture were poured in mineral oil for W/O emulsification. The magnetic properties of the nano-aggregates were confirmed by vibrating sample magnetometer (VSM), suggesting that incorporation of mPEG-PCL slowly decreased T2-relaxation time. Dynamic light scattering (DLS) showed incorporation of mPEG-PCL decreased particle sizes. Encapsulation efficiencies of the magnetite nano-aggregate were also affected by the amount of mPEG-PCL in the aggregates. |
| 저자 |
정현아1, 김혜성1, 박신영1, 최지숙1, 유혁상1, 김수경2
|
| 소속 |
1강원대, 2포항공과대 |
| 키워드 |
magnetite; microsphere; iron oxide; mPEG-PCL; MRI
|
| E-Mail |
|
