| 학회 |
한국고분자학회 |
| 학술대회 |
2009년 가을 (10/08 ~ 10/09, 광주과학기술원 오룡관) |
| 권호 |
34권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Co-electrospun nanofiber containing two different growth factors for wound healing |
| 초록 |
Coaxial electrospinning received much attention because water-soluble protein in aqueous phase can be electrospun with polymers in organic phase. In this study, we prepared a coaxial nanofiber (NF) simultaneously containing encapsulated bFGF and chemically-immobilized EGF. For coaxial electrospinning, the outer solution composed of a mixture of PCL-PEG and PCL in a chloroform/MEOH mixture and the inner solution composed of bFGF in 1% PVA solution were electrospun to NF (flow rate=0.1/1.0 (ml/h, in/out)). For surface modification, EGF was reacted with surface-exposed amine groups of the NF. Wound healing efficacy of the NF was tested in female C57BL/6 mice with diabetic ulcers at dorsal area. Coaxial electrospinning successfully generated NFs with a core-shell structure. Because bFGF was encapsulated completely inside the NF, the NF with the conjugated EGF showed a significant peak of N1s however bFGF NF not shown. A coaxial NF can be a superior candidate for wound healing. |
| 저자 |
최지숙1, 유혁상1, 박신영1, 김혜성1, 정현아1, 김현준2, 정지훈2, 손세진3, 김원종3
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| 소속 |
1강원대, 2성균관대, 3포항공과대 |
| 키워드 |
coaxial; electrospinning; nanofiber; wound healing; growth factor
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| E-Mail |
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