| 초록 |
The acylation of 2-methoxynaphthalene(2-MON) with acetic anhydride has been investigated in the liquid phase over the H-forms of beta zeolite with different Si/Al ratios as catalyst. Initial reaction rate and turnover frequency increase in a significant extent with increasing Si/Al ratio. This behavior seems to be related to the presence of stronger acid sites existing in the catalyst and the increased hydrophobicity exhibited by zeolite posessing high Si/Al ratio. Zeolite beta with the low Si/Al ratio shows the highest selectivity to 2-acetyl-6-methoxynaphthalene, an important intermediate for the synthesis of Naproxen. This is mainly due to the direct acylation of 2-MON. In the case of zeolite beta with high Si/Al ratio, the isomerization of 1,2-AMON to 2,6-AMON reaction pathway is more pronounced than the direct acylation.Deactivation is observed in a quite short reaction rime, which also plays a role in determining the product distribution. |
