| 학회 |
한국고분자학회 |
| 학술대회 |
2014년 가을 (10/06 ~ 10/08, 제주 ICC) |
| 권호 |
39권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
The effect of Carrier for BMP-2 Delivery on Histological Aspects of Tissue-Engineered Bone |
| 초록 |
Bone morphogenetic protein-2 (BMP-2) that can regenerate bone by recruiting osteo-progenitor cells and inducing osteogenic differentiation has been highlighted as an alternative therapy to treat bone defects. The therapeutic effect of BMP-2 depends on the delivery carriers. In this study, we directly compared the quality of regenerated bone when BMP-2 was delivered with collagen or fibrin, both of which are shown to be excellent carrier for BMP-2. The microstructure, surface morphology, BMP-2 release profile was examined in vitro. To evaluate the quality of regenerated bone, both types of BMP-2 carriers were implanted into the dorsal subcutaneous spaces of the mice. 4 ~ 6 weeks after implantation, the regenerated bone was evaluated by computed tomography, histology, and histomorphometric analysis. The bone regeneration by the collagen with BMP-2 was higher bone density than bone regenerated by the fibrin with BMP-2. 사사;NRF-2012R1A1A2008403 |
| 저자 |
조명옥1, 장현석2, 김기석3, 허강무1, 강선웅2
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| 소속 |
1안전성평가(연), 2충남대, 3고려대 |
| 키워드 |
BMP-2; Collagen gel; Fibrin gel; Bone regeneration
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| E-Mail |
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