| 학회 |
한국공업화학회 |
| 학술대회 |
2019년 가을 (10/30 ~ 11/01, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 |
23권 2호 |
| 발표분야 |
포스터_생물공학 |
| 제목 |
Systematic Analysis on Transcription Unit Architecture of Streptomyces lividans TK24 |
| 초록 |
Streptomyces lividans is an attractive host for heterologous production of proteins and secondary metabolites. In this study, the transcription unit (TU) architecture of S. lividans was elucidated by integrating four high-throughput data types, including dRNA-Seq, Term-Seq, RNA-Seq and Ribo-Seq. Total 1,300 TUs and the corresponding regulatory elements were elucidated from 1,978 transcription start sites and 1,640 transcript 3´-end positions. The TU information and regulatory elements identified will serve as invaluable resources for understanding the regulatory mechanisms of S. lividans and to elevate its industrial potential. This work was supported by the Novo Nordisk Foundation (NNF10CC1016517). This work was also supported by the Intelligent Synthetic Biology Center of Global Frontier Project (2011-0031957) and the Bio & Medical Technology Development Program (2018M3A9F3079664) through the National Research Foundation of Korea funded by the Ministry of Science and ICT. |
| 저자 |
이용재1, 이남일1, 정유진1, 황순규1, 김우리1, 조수형1, Bernhard O. Palsson2, 조병관1
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| 소속 |
1KAIST, 2Univ. of California San Diego / Novo Nordisk Foundation Center for Biosustainability |
| 키워드 |
Streptomyces; transcription; transcription start site; transcription termination; transcription unit
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| E-Mail |
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