| 학회 |
한국고분자학회 |
| 학술대회 |
2013년 가을 (10/11 ~ 10/12, 창원컨벤션센터) |
| 권호 |
38권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Preparation of Tramadol-HCl Loaded Microsphere for Control Release |
| 초록 |
Tramadol-HCl (TH) is a weak μ-opioid receptor agonist and a reuptakes inhibitor of serotonin and of norepinephrine. Hydrophobic polyoxalate (POX) has been suggested for use in biodegradable medical devices such as H2O2-sensitive bioimaging probe and controlled release formulation. In this study, we developed tramadol-encapsulated POX microspheres by changing molecular weight of the POX and methods to prepare microsphere including W1/O/W2, O1/O2/W, O/W, and O1/O2. The inner and outer morphology and physicochemical properties of TH-encapsulated POX microspheres was characterized using SEM, XRD, DSC, FT-IR and HPLC. Through the study results, it shows that the source of the skin layer of TH-loaded microspheres is comprised of POX polymer and TH was encapsulated within the microsphere. Also, the release behavior can be effectively controlled by the preparation method. This research was supported by MIFAFF (112007-05-1-SB010) and MEST (2012M3A9C6050203) |
| 저자 |
이천중, 조선아, 김경희, 오승창, 이동원, 강길선
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| 소속 |
전북대 |
| 키워드 |
tramadol-HCl; polyoxalate; microsphere; PLGA
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| E-Mail |
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