| 초록 |
Efficient downstream process can depend strongly on their physicochemical properties such as size and crystal habit. Especially, crystal habits of high aspect ratios such as needle-like by anisotropic growth have difficulties due to low flowability and packing, and vulnerability to particle damages. To solve this problem, we used a simple porous device for uniform particle production of lower aspect ratio of drug particles. In this study, the drowning-out crystallization with porous devices was investigated using naproxen, a nonsteroidal anti-inflammatory drug, and we confirmed that the effect of the porous device system in the drowning-out crystallization by using other various drugs. By using this simple method,It was possible to save additional cost, time and energy, solving the problems of the downstream processes occurring in the various industries. |
