| 초록 |
Processing cost of downstream unit operations in the pharmaceutical industry are strongly influenced by the physico-chemical properties of drug. Especially, high aspect ratio of drug particles with unfavorable crystal habits such as needle-like have difficulties in Industrial processes due to low efficiency of flowability and packing. To solve these problems, we added simple porous devices to enable uniform particle production with lower aspect ratio of the drug particles. Porous device induced heterogeneous nucleation in the solution, resulting in accelerated nucleation. In this study, the drowning-out crystallization with porous devices was examined using various drugs, and we confirmed that effect of the porous devices on aspect ratio, particle size, etc. Through this method, it was possible to reduce the energy for changing the properties of the drug particle, the additional cost, and time, and to solve the problem of the overall downstream process occurring in the industry. |
