| 학회 | 한국화학공학회 |
| 학술대회 | 2009년 가을 (10/22 ~ 10/23, 일산 KINTEX) |
| 권호 | 15권 2호, p.1433 |
| 발표분야 | 공정시스템 |
| 제목 | A system framework toidentify promising enzyme candidates to synthesize novel pathways to produce desired biochemical |
| 초록 | We propose a systematic approach and related framework with the aim of predicting novel synthetic pathways for desired chemicals at a reliable level. To allow applications to in vivo or in vitro systems, we considered factors that can affect the novel pathways. There are five factors that evaluate three types of abilities: similarity, thermodynamics, and coexpression. The five factors are binding site covalence, chemical similarity, thermodynamic favorability, pathway distance, and organism specificity. We suggest a method to evaluate these factors and obtain priority scores which rank identified pathways. The factors are evolutionary fitted and thus the system is optimized itself. Our approach will enhance the production of high value added chemicals and biofuels. ACKNOWLEDGEMENT This work was supported by the Korean Systems Biology Research Program (M10309020000-03B5002-00000) of the Ministry of Education, Science and Technology (MEST). Further supports by LG Chem Chair Professorship, Microsoft, World Class University Program of MEST and IBM-SUR program are greatly appreciated. |
| 저자 | 조아연, 윤홍석, 이상엽, 박선원 |
| 소속 | 한국과학기술원 |
| 키워드 | Systems Biology; Pathway Synthesis |
| 원문파일 | 초록 보기 |
