| 학회 |
한국고분자학회 |
| 학술대회 |
2012년 봄 (04/12 ~ 04/13, 대전컨벤션센터) |
| 권호 |
37권 1호 |
| 발표분야 |
Biopolymer-Based Hybrid Materials for Sensing and Delivery |
| 제목 |
Synthesis and Characterization of Mannose-PEG-linked Superaramagnetic Iron Oxide Nanoparticles specifically targeted to antigen presenting cells for MR imaging on Lymph Node |
| 초록 |
The aim of the study is to prepare biocompatible and specifically targetable nanoparticles to lymph nodes (LN) for LN specific MRI. Previously many contrast agents have been developed to target to antigen-presenting cells for LN detection by MRI. In this study, mannose-PEG was prepared from D-mannopyranosylphenyl isothiocyanate and Amine PEG Carboxyl. The APTES-activated SPION and mannose-PEG was crosslinked to produce mannose-PEG-linked SPION. Mannose on the surface achieved efficient targeting to mannose receptor on antigen presenting cells. PEG corona layer prevented from aggregation during the systemic circulation with accompanying enhanced specificity and minimized systemic toxicity. In in vivo study, rats were intravenously injected with Mannose-PEG-SPION and tracked by MR imaging. MR imaging on LN clearly revealed the preferential uptake of Mannose-PEG-SPION in immune cells-rich lymph nodes. The accumulation in LN was also confirmed by Prussian blue staining. |
| 저자 |
MUTHUNARAYANAN MUTHIAH1, Hieu Vu-Quang1, 김유경2, 조종수2, 이준행1, 정용연3, 박인규1
|
| 소속 |
1전남대, 2서울대, 3화순전남대 |
| 키워드 |
Mannose-SPION; MR imaging; Lymph Node
|
| E-Mail |
|
