| 학회 |
한국공업화학회 |
| 학술대회 |
2020년 가을 (10/28 ~ 10/30, 광주 김대중컨벤션센터(Kimdaejung Convention Center)) |
| 권호 |
24권 1호 |
| 발표분야 |
포스터-생체재료 |
| 제목 |
Simultaneous delivery of antigen and immune-modulator using nano micelle-generating dissolving microneedle array for enhanced cancer vaccination. |
| 초록 |
Dissolving microneedle (dMN), one of the various MNs, has been considered as an attractive method for transcutaneous immunization due to its superior ability to deliver vaccines through the skin layer. Here, we develop pluronic-based dMNs that generate nanomicelles (NMCs) upon their dissolution after cutaneous application, which facilitate the efficient encapsulation of poorly water-soluble toll-like receptor 7/8 agonist (R848) and the delivery of hydrophilic antigens. The sizes of NMCs range from 3-40 nm, which is suitable for the efficient delivery of R848 and antigens to lymph nodes and promotion of cellular uptake by APCs, minimizing systemic exposure of the R848. Application of MNs containing tumor model antigen (OVA) and R848 to the skin of EG7-OVA tumor-bearing mice induced a significant level of antigen-specific humoral and cellular immunity, resulting in remarkable anti-tumor activity. |
| 저자 |
임수연, 김다훤, 정재백, 조희주, 김동민, 정지훈
|
| 소속 |
성균관대 |
| 키워드 |
microneedle; resiquimod; cancer vaccination
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| E-Mail |
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