| 학회 |
한국고분자학회 |
| 학술대회 |
2008년 가을 (10/09 ~ 10/10, 일산킨텍스) |
| 권호 |
33권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Polypeptide secondary structurecontrols thermosensitivity ofblock copolymers |
| 초록 |
We are reporting that the β-sheet structure of L-polyalanine plays a critical role in developing a fibrous nanostructure as well as sol-to-gel transition of amphiphilic poly(ethylene glycol)-L/or DL-polyalanine diblock copolymers. L-isomers underwent transitions from random coils to β-sheets, and to nanofibers as the polymer concentration increased, whereas DL-isomer remained as a random coil structure without developing any specific nanostructure. At high polymer concentrations, the aqueous polymer solutions underwent sol-to-gel transition as the temperature increased, so called, reverse thermal gelation. The L-isomer with a preassembled β-sheet secondary structure facilitates the sol-to-gel transition than the DL-isomer with a random coil structure. |
| 저자 |
최윤영, 주민경, 박민희, CHI BO, 정병문
|
| 소속 |
이화여자대 |
| 키워드 |
polypeptide; sol-gel transition; secondary structure
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| E-Mail |
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