| 학회 |
한국화학공학회 |
| 학술대회 |
2007년 봄 (04/19 ~ 04/20, 울산 롯데호텔) |
| 권호 |
13권 1호, p.330 |
| 발표분야 |
분리기술 |
| 제목 |
Fine Particle Formation of Itraconazole using Supercritical Carbon Dioxide via Aerosol Solvent Extraction System (ASES) and Evaluation of its Material Property |
| 초록 |
Crystallization of Itraconazole has many difficulties because of its low solubility and bioavailability. The main purpose of this research is to find the improved dissolution rate of Itraconazole using supercritical fluid technology. In the present research, particle formation is accomplished by Aerosol Solvent Extraction System (ASES) using sc-CO2as antisolvent. The investigated conditions are 35℃~50℃, 125bar~200bar and 20g/min~40g/min. The precipitated particles were measured particle size distribution and morphology using SEM, PSA and drug release study get accomplished according to dissolution rate. Physical properties are investigated as verifying XRD and DSC data. The shape of raw materials is needle type and the size is about 15㎛ in length. After process shape is changed to plate type and the size of processed particles is about 5㎛~10㎛. As DSC result, melting point drops about 2℃ and the crystallinity of processed particles is changed to more amorphous than that of raw material. Therefore dissolution rate of processed itraconazile is very improved compared to raw material. |
| 저자 |
윤용석, 주준호, 김대성, 정진성, 김화용, 이윤우
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| 소속 |
서울대 |
| 키워드 |
Supercritical carbon dioxide; Itraconazole; Recrystallization; ASES;
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| E-Mail |
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| 원문파일 |
초록 보기 |
