| 학회 |
한국공업화학회 |
| 학술대회 |
2016년 봄 (05/02 ~ 05/04, 여수 엑스포 컨벤션) |
| 권호 |
20권 1호 |
| 발표분야 |
우수논문(구두)_석사과정 |
| 제목 |
Potency of silk/β-Tricalcium Phosphate Scaffolds as Biomaterial for Bone Repair |
| 초록 |
Silk fibroin is a biomaterial for biomedical applications because it has a number of attractive properties such as biocompatibility and biodegradability. However, it has a lack of mechanical properties for bone replacement graft material. To increase osteoconductivity and osteoinductivity, mechanical property and osteoconductivity of silk scaffold were modified by β-tricalcium phosphate (β-TCP). β-TCP as a type of bioceramics has degradable, osteoconductive and minimal cytotoxicity. Physical and chemical characterizations of silk/β-TCP scaffolds were determined by SEM, compressive strength, and FT-IR, etc. Also, osteogenic differentiation of rabbit bone marrow mesenchymal stem cells (rBMSCs) cultured in scaffold was assessed using alkaline phosphatase (ALP), MTT, RT-PCR, and SEM. These results showed that silk/β-TCP (75:25) scaffold was higher cell proliferation and differentiation of rBMSCs compared with other groups. |
| 저자 |
이대훈1, 차재근1, 신재훈1, 국연지1, 전유신1, 송정은1, 박찬흠2, 강길선1
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| 소속 |
1전북대, 2한림대 |
| 키워드 |
silk; scaffold; osteogenic differentiation; biomaterial
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| E-Mail |
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