| 학회 |
한국고분자학회 |
| 학술대회 |
2009년 가을 (10/08 ~ 10/09, 광주과학기술원 오룡관) |
| 권호 |
34권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Effects of Surface-Immobilized Nano-Hydroxyapatite on the In Vivo Bone-Regenerative Performance of Porous Polymer Scaffolds |
| 초록 |
Nano-hydroxyapatite (N-HAp) has been used as a main component of bioactive nanocomposites for bone regeneration. Of many interesting properties, the cell-friendly features of N-HAp are ascribed to its surface structure. Thus, exposing N-HAp on the surface is an important issue in fabricating nanocomposites. Herein, we develop porous polymer scaffolds with immobilized N-HAp on pore surfaces. The porous poly(L-lactide) (PLA) scaffolds with surface-immobilized N-HAp provide more favorable environments than conventional bulk-mixed hybrid scaffolds in terms of cell growth. In vivo biological evaluation showed that the scaffolds with surface-exposed N-HAp provided favorable environments for enhanced bone growth. Acknowledgement. This research was supported by a grant (code #: 2009K000430) from ‘Center for Nanostructured Materials Technology’ under ‘21st Century Frontier R&D Programs’ of the Ministry of Education, Science and Technology, Korea. |
| 저자 |
구안나1, 김성은1, 이홍재1, 전성현2, 채지화2, 강계원2, 이상천1
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| 소속 |
1경희대, 2한스바이오메드 |
| 키워드 |
nano-hydroxyapatite; surface-immobilization; bone regeneration; porous poly(L-lactide) scaffolds
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| E-Mail |
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