| 학회 |
한국고분자학회 |
| 학술대회 |
2017년 봄 (04/05 ~ 04/07, 대전컨벤션센터) |
| 권호 |
42권 1호 |
| 발표분야 |
대학원생 구두발표 (발표15분) |
| 제목 |
Amphiphilic Poly(Amino Acid) based Adjuvants including Squalene for Influenza Virus Vaccine |
| 초록 |
As the outbreak of infectious disease is getting more frequent and devastated year by year, the advent of more efficient vaccine is greatly expected. Therefore, the development of better adjuvant accompanied with vaccine for enhancing immunogenicity has been greatly required. Herein, we address nanocomplex of amphiphilic grafted poly(amino acid) and hydrophobic squalene (PA/S-NC) as a potent adjuvant against influenza virus. The results showed that PA/S-NC performed proper loading efficiency and stability. More importantly, IM co-administration of PA/S-NCs and an H1N1 pandemic strain (CA04) produced antibodies and cytokines in a conditional mouse model. Furthermore, The PA/S-NC/CA04 vaccination prevented disease symptoms and protected mouse model against lethal infection with H1N1 virus. Consequently, our PA/S-NCs could be one of great potent adjuvant for enhancing vaccine-induced immune responses. |
| 저자 |
임종우1, 김현욱1, 나운성2, 염민주2, 김지혜1, 박근선1, 천해진1, 송대섭2, 함승주1
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| 소속 |
1연세대, 2고려대 |
| 키워드 |
백신; 아미노산고분자; 스쿠알렌
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| E-Mail |
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