| 학회 |
한국고분자학회 |
| 학술대회 |
2017년 봄 (04/05 ~ 04/07, 대전컨벤션센터) |
| 권호 |
42권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 I |
| 제목 |
Stent comprising CD44-targeted polymeric prodrug releasing paclitaxel and gemcitabine in a time interval managed manner for synergistic human biliary cancer therapy |
| 초록 |
Drug eluting stents (DES) have been proposed as promising strategy for human biliary cancer. In this report, we designed temporally controlled polymeric multi prodrug nanoparticle (TCMPN) eluting stents consisting of polyurethane (PETE) nano-fiber as a polymeric matrix and paclitaxel (PTX) loaded CD44-targeting hyaluronic acid conjugated poly (lactic-co-glycolic acid) and gemcitabine (PLGA-HA-GEM). TCMPN enabled temporal release of two drugs, that PTX was released first due to the collapse of structure in endosomes and GEM was hydrolyzed from PLGA-HA-GEM later in response to low pH, which inducing synergistic anticancer activities and when being embedded in PETE nano-fiber showed low initial burst value and sustainable prodrug release in vitro. These results indicate that this technology will open up avenues for cancer therapy by combining localized delivery and functional multi drug loaded nanoparticles. |
| 저자 |
박근선1, 윤다연1, 김현욱1, 노일구2, 김지혜1, 임종우1, 이훈재3, 천해진1, 함승주1
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| 소속 |
1연세대, 2한국과학기술원, 3연세의료원 |
| 키워드 |
- |
| E-Mail |
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