| 초록 |
Microtubules (MTs) are 25 nm protein nanotubes, comprised of globular dimeric α-β- tubulin subunit, aligned end-to-end to form linear protofilament, and forms hollow cylinder. MTs are involved in a variety of cellular functions, including cell division, intracellular transport, and cell morphology. In neuron, MTs form bundle structure mediated by microtubule-associated-protein (MAP) tau, which is known to hallmark of Alzheimer’s disease. We discuss our recent findings on hierarchical assembly structures of MTs with polylysine as a model cationic polymer for MAP by using transmission electron micrography (TEM) and small angle x-ray scattering (SAXS). Supported by NRF 2011-0031931, 2011-0030923, 2012R1A1A1011023, 2011-355-C00037, KAIST N10110077, and G04100061. |
