| 학회 |
한국고분자학회 |
| 학술대회 |
2015년 봄 (04/08 ~ 04/10, 대전컨벤션센터) |
| 권호 |
40권 1호 |
| 발표분야 |
고분자가공/복합재료 |
| 제목 |
Effect of nanotopology on senescence of hASC |
| 초록 |
In a native tissue, cells are embedded within an extracellular matrix (ECM), which have sub-micron to nanometer-scale topographies. Therefore, the topography of cell culture substrate or microenvironment during in vitro culture has a critical effect on cell behavior in maintaining their normal phenotypic and molecular characteristics. In this study, we prepared various nano patterned surfaces; line/space, hexagonal, and square array. To investigate their effect on morphology and senescence of hASC, cells were seeded and cultured on different nano patterns. The influence of the nanoscale-patterns was observed on proliferation, viability, morphology, cell-matrix interaction, and senescence of hASCs. |
| 저자 |
김지호1, 문보경2, 유승정3, 박세아2, 최보규2, 임성갑4, 이수홍2
|
| 소속 |
1차의과대, 2차의과학대, 3KAIsT, 4KAIST |
| 키워드 |
Nanopattern; MSC; Senescence
|
| E-Mail |
|
