| 학회 |
한국고분자학회 |
| 학술대회 |
2015년 봄 (04/08 ~ 04/10, 대전컨벤션센터) |
| 권호 |
40권 1호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
Osteogenic Differentiation of Human Adipose-Derived Stem Cells Is Promoted Through Remodeling of Type I Collagen by MMP-13 |
| 초록 |
Matrix metalloproteinases (MMPs) has the essential role for the cell biology through cleavage of extracellular matrix (ECM) proteins. Bone tissue is mainly composed of type I collagen (ColI), which is known to promote osteogenic differentiation of human adipose-derived stem cells (hASCs). However, still not clear that the mechanism of enhancing osteogenic differentiation by ColI. It has been proven that cell-matrix interaction plays an important role in osteogenic differentiation of hASCs. MMP-13 is significantly increased in hASCs during osteogenic differentiation on ColI. After osteogenic induction, the mRNA expression levels of both ITGA3 and RUNX2 increased significantly on ColI-coated plates. MMP-13 has a role as a regulatory factor in bone formation, which is regulated by transcription factor RUNX2. These results collectively suggest that hASCs-ColI interaction can enhance osteogenic differentiation through ColI/MMP-13 positive feedback loop. |
| 저자 |
아라이 요시에1, 최보규1, 한인보2, 이수홍1
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| 소속 |
1차의과학대, 2차병원 |
| 키워드 |
Mesencymal Stem Cells; MSC; Osteogenic Differentiation; MMP-13; Integrin
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| E-Mail |
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