| 학회 |
한국공업화학회 |
| 학술대회 |
2018년 가을 (10/31 ~ 11/02, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 |
22권 2호 |
| 발표분야 |
우수논문(구두)_박사과정 |
| 제목 |
Intra-hepatocyte Invagination and Treatment for Liver Disease based on Drug-Loaded Surface Modified Ceria-Zirconia Nanoparticles |
| 초록 |
Oxidative stress in the mitochondria is important pathologic factor in generally liver disease, including cirrhosis. Ceria nanoparticles (CNPs) have two oxidation states, Ce3+ and Ce4+ which have stimulated researchers to study CNPs as therapeutic agents for treating numerous diseases, including cancer. Ceria-zirconia nanoparticles (CZNPs) are control higher Ce3+/Ce4+ ratio and faster change from Ce4+ to Ce3+ that those indicated by ceria nanoparticles. Thus, mitochondria-reactive oxygen species targeting surface modified CZNPs might be a potential of therapeutic apply to generally liver diseases. In this study, we report the synthesis of surface modified CZNPs that selectively to mitochondria and inhibit hepatocyte death in a liver disease model. |
| 저자 |
홍상은1, 최성윤1, 홍하은2, 김옥희2, 김세준2, 윤국로1
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| 소속 |
1한남대, 2카톨릭대 |
| 키워드 |
Liver Disease; Ceria-Zirconia Nanoparticle; Reactive Oxygen Species; Ceria Nanoparticle; Mitochondria
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| E-Mail |
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