| 학회 | 한국공업화학회 |
| 학술대회 | 2022년 봄 (05/11 ~ 05/13, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 | 26권 1호 |
| 발표분야 | 포스터-생체재료 |
| 제목 | Proinflammatory responses of macrophages by treatment of pectin from root bark of Ulmus davidiana var. japonica |
| 초록 | Modulation of macrophage polarization isa promising method in cancer and inflammatory disease therapies. Hence, a lotof immunomodulating materials have been studied to maximize the therapeuticeffect on a specific disease. In this study, we evaluated immune activity of pectin,which was isolated from root bark of Ulmusdividana var. japonica (UDP). Weconfirmed that UDP increased the activity of human macrophages (U937- andTHP-1-derived macrophages). The UDP treatment induced M1 polarization ofmacrophage (THP-1) with apparent upregulation of pro-inflammatory compared withU937-derived macrophages. It might be caused by pectin recognitionreceptor-mediated internalization of UDP. Actually, we found various TLRs werehighly expressed than those of U937 macrophages. |
| 저자 | 최재호, 기창석 |
| 소속 | 서울대 |
| 키워드 | pectin; immunomodulation; macrophage; Ulmus davidiana var. japonica |
