초록 |
Stimuli-responsive polymeric micelles are composed of a hydrophilic shell and a responsive hydrophobic core with tunable solubility that depends on external stimuli. If a responsive hydrophobic core contains a covalently attached drug moiety which is labile to external stimuli, one can achieve site-specific and time-controlled delivery of therapeutics to improve therapeutic efficacy.For this purpose, we synthesized a diblock copolymer composed of a hydrophilic poly(ethylen oxide)(PEO) block and a drug-containing hydrophobic block by a combination of atom transfer radical polymerization (ATRP)and a copper-catalyzed azide-alkyne click chemistry.In aqueous solution, this block copolymer self-assembled to form micelles in which the drug-containing hydrophobic block forms the inner core, and the hydrophilic PEO the outer shell. Irradiation with UV light led to cleavage and subsequent release of the drug moiety. |