화학공학소재연구정보센터
학회 한국고분자학회
학술대회 2010년 가을 (10/07 ~ 10/08, 대구 EXCO)
권호 35권 2호
발표분야 기능성 고분자
제목 UV Responsive system by functional polymer material
초록 Stimuli-responsive polymeric micelles are composed of a hydrophilic shell and a responsive hydrophobic core with tunable solubility that depends on external stimuli. If a responsive hydrophobic core contains a covalently attached drug moiety which is labile to external stimuli, one can achieve site-specific and time-controlled delivery of therapeutics to improve therapeutic efficacy.For this purpose, we synthesized a diblock copolymer composed of a hydrophilic poly(ethylen oxide)(PEO) block and a drug-containing hydrophobic block by a combination of atom transfer radical polymerization (ATRP)and a copper-catalyzed azide-alkyne click chemistry.In aqueous solution, this block copolymer self-assembled to form micelles in which the drug-containing hydrophobic block forms the inner core, and the hydrophilic PEO the outer shell. Irradiation with UV light led to cleavage and subsequent release of the drug moiety.
저자 최종휘, 이형일
소속 울산대
키워드 UV Responsive system; ATRP
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