| 초록 |
Methyl methacrylate (MMA), methoxy poly(ethylene glycol) monomaleate (MPEG), and acrylamidoglycolic acid (AGA) terpolymeric microgels (MGs) have been synthesized by free radical surfactant-free emulsion polymerization. The MGs were crosslinked with ethyleneglycol dimethacrylate (EGDMA) and the chemical crosslinking was confirmed by FTIR. 5-fluorouracil (5-FU), a model anticancer drug, has been loaded by in situ and adsorption method into the MGs. Plain as well as drug loaded MGs have been characterized by TEM, DSC, and XRD. DSC and XRD studies have indicated a molecular level dispersion of the drug in PMMA MGs during in situ loading. TEM images have shown the formation of spherical MGs. In-vitro release of 5-FU from the crosslinked poly(MMA-co-AGA-co-MPEG) MGs was investigated at 7.4 pH and 1.2 pH buffer medium that indicated the controlled release of drug up to ~18 h. |
