| 학회 | 한국고분자학회 |
| 학술대회 | 2003년 가을 (10/10 ~ 10/11, 부경대학교) |
| 권호 | 28권 2호, p.382 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Sol-gel Transition Behavior of Biodegradable PLGA-PEG Triblock and Star-Block Copolymer Solution |
| 초록 | Recently, biodegradable linear block copolymers of PEG and polyester have been investigated intensively to make up for disadvantages of Pluronic, which has attracted considerable attention to be used as injectable drug delivery. In this study, biodegradable triblock and 3armed, 4armed star-shaped block copolymers of poly(ethylene glycol) (PEG) and poly(DL lactide-co-glycolide) (PLGA) were synthesized by using nontoxic ethylene glycol, glycerol and pentaerythritol as initiators. The sol-gel transition behavior of star-shaped block copolymer was compared with that of triblock copolymer and their blends. The temperature-dependent sol-gel transition behavior of the concentrated solution was investigated by the tube tilting method. The critical micelle concentration and micelle size of resulting products were determined by UV-Vis spectroscopy and dynamic light scattering. From this work, the effects of architecture and the number of arms of star block copolymer on the sol-gel transition behavior and micellization were investigated. |
| 저자 | 이수정1, 한보령2, 박상엽1, 한동근2, 김성철1 |
| 소속 | 1한국과학기술원, 2기능성고분자신소재연구센터 |
| 키워드 | sol-gel transition; temperature-sensitive polymer; star-shaped |
