| 초록 |
Hydrogels responding to external stimuli have been extensively utilized for controlled drug delivery. Ferrogels responding to the magnetic field also demonstrated potential in delivery of drug and/or cell. In this study, alginate-based ferrogel was prepared and used to modulate anti-cancer drug delivery. Alginate is a widely used biomaterial in many drug delivery applications due to its biocompatibility, low toxicity, and mild gelation. However, studies on alginate-based ferrogel are still lacking, as the gel has very limited porous structure. We thus incorporated gelatin microspheres into alginate ferrogel, which resulted in enhanced deformation degree of the ferrogel. Doxorubicin (DOX) was chosen as a model and its release from alginate ferrogels with different porous structures was monitored in vitro. The therapeutic effect of ferrogel was also evaluated in a tumor-bearing mouse model. This approach may be useful in the design of delivery vehicles for many biomedical applications. |
