| 초록 |
Drug-loaded polymeric nanoparticles have been widely used in cancer therapy due to their reduced toxicity and enhanced therapeutic efficacy. Recently polymeric nanoparticles have been developed for the cancer theragnosis. We expected polymeric nanoparticles which generate carbon dioxide triggering the release of anti-cancer drug at the tumor could be useful for the cancer treatment. Alkyl carbonate-modified poly(ethylene glycol) was synthesized, and the carbonate linkage formation and its hydrolysis at physiological conditions were confirmed by FT-IR and H-NMR. Drug-loaded gas-generating nanoparticles were prepared by solvent evaporation method. Various properties of nanoparticles, including size, shape, cytotoxicity, and drug release profile were tested. The therapeutic efficacy of drug-loaded gas-generating nanoparticles in a tumor-bearing mouse model was also evaluated. These multifunctional and biocompatible nanoparticles may provide a useful means of cancer diagnosis and therapy. |
