| 초록 |
Poly(ethylene glycol) (PEG) has been extensively investigated in many biomedical applications, and PEG-based amphiphiles have been widely utilized to date in the preparation of polymer micelles for diagnosis and treatment of various diseases. We hypothesized that PEG-alkyl carbonate could be useful to form gas-generating polymer micelles for cancer diagnosis and therapy. PEG-alkyl carbonate was synthesized via alkyl halide reaction. Various characteristics of gas-generating polymer micelles, including morphology, size and size distribution and gas-generating capability via hydrolysis of the carbonate linkage were investigated. The cytotoxicity and intracellular uptake of micelles were also investigated in vitro. Gas-generating polymer micelles significantly inhibited the tumor growth when intravenously injected into the tumor bearing mouse model. This approach may be promising to develop drug delivery systems for the treatment of various diseases, including cancer. |
