| 학회 |
한국화학공학회 |
| 학술대회 |
2006년 봄 (04/20 ~ 04/21, 대구 인터불고 호텔) |
| 권호 |
12권 1호, p.2 |
| 발표분야 |
고분자 |
| 제목 |
Novel pH-responsive polymeric micelles:Paclitaxel release behaviors |
| 초록 |
Among various carrier systems, polymeric micelles composed of pH-responsive block copolymers can strengthen the anti-tumor efficiency of a drug by storing in the target area. Site-targeted drug delivery system also can be used to achieve enhanced therapeutic effect and minimize the harmful side effect of the drug. Poly(ß-amino esters) including ionizable groups is ionized below pKb and deionized above pKb. We synthesized methoxy poly(ethylene glycol)-poly(ß-amino esters) block copolymers with different molar ratios and various bisacrylate ester by Michael type step polymerization. We used Paclitaxel (PTX) as hydrophobic drugs so that we observed characterizations of drug carrier behaviors. |
| 저자 |
한종권, 황수종, 김민상, 이두성
|
| 소속 |
성균관대 |
| 키워드 |
micelle; pH-responsive; ß-amino ester; Paclitaxel
|
| E-Mail |
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| 원문파일 |
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