| 학회 |
한국고분자학회 |
| 학술대회 |
2008년 가을 (10/09 ~ 10/10, 일산킨텍스) |
| 권호 |
33권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
PLGA/gelatin/HAp composite nanofibrous scaffolds for bone regeneration |
| 초록 |
Biomimetic nanofibrous poly(L-lactide-co-glycolide) (PLGA)/gelatin/hydroxyapatite (HAp) composite scaffolds were electrospun for bone tissue engineering. The blends of PLGA, gelatin (blending ratio; 0, 30, 70, and 100 wt%; gelatin to PLGA) with HAp were electrospun and the amount of HAp on a surface of nanofibers was determined. The properties of composite scaffolds were characterized by the SEM, TGA, DSC, mechanical test, wettability, water uptake and ATR-FT-IR. Mean diameter of electrospun fibers was increased with increase of gelatin content or incorporating of HAp. HAp particles were observed on a surface area of nanofibers in proportion to gelatin amount. The cell adhesion and proliferation were increased in composite nanofibers compared to PLGA nanofiber. These results indicated that incorporated gelatin causes the exposition of HAp to the surface of polymeric fiber. |
| 저자 |
이정복1, 허동녕2, 정성인1, 전흥재2, 문성환1, 김성은2, 권일근3
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| 소속 |
1경희대, 2구강생물학(연), 3연세대 |
| 키워드 |
PLGA; gelatin; hydroxyapatite; composite; nanofiber; osteoblast
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| E-Mail |
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