| 초록 |
For wound healing, scaffold has to protection of injury, removal of exudation, inhibition of outside interference and improved mechanical property. In this study, the blending solutions of elastic polyurethane (PU) and hydrophilic gelatin (blending ratio; 0, 30, 50, 70 and 100% gelatin to PU) were electrospun. The characteristics of gelatin/PU blended nanofibrous scaffolds were examined such as morphological, biomechanic, surface property and wettability. The gelatin/PU nanofibrous blended scaffolds seeded with NIH3T3 cells and the modulation of adhesion, proliferation, and cytotoxicity was analyzed by MTT test. The mean diameter of nanofibers was uniformly electrospun ranged from 0.4 to 2.1 μm. According to the result, when amount of gelatin in blended solution decreased, contact angle increased and water uptake of the scaffold got lower concurrently. Regarding mechanical test, the blended nanofibrous scaffolds were elastic that total amount of PU increased. |
