| 학회 |
한국고분자학회 |
| 학술대회 |
2010년 봄 (04/08 ~ 04/09, 대전컨벤션센터) |
| 권호 |
35권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Characterization of Valsartan Tablet using Hydroxypropylmethylcellulose depends on various Viscosity |
| 초록 |
Valsartan, a selective angiotensin Ⅱ type 1 receptor(AT1R) antagonist, has high bioavailability. We prepared sustained-release drug by using direct compression. This tablet was formulated by using CMC as a excipient and HPMC as a disintegrator. SEM was used to observe the dissolution behavior of valsartan tablet. Crystallinity of valsartan, additives and valsartan tablet was analyzed by using DSC. FT-IR was used to analyze the change of structure between valsartan, additives and valsartan tablet. The in vitro test was carried out to confirm whether valsartan tablet is soluble in intestinal juice, and controlled experiment was carried out to compare valsartan tablet with conventional drugs(Diovan80 mg). The in vitro test found sustain-release of valsartan tablet. This studies showed sustained-release of valsartan tablet by direct compression, valsatan as orally pharmaceutical sustained-release formulation. |
| 저자 |
홍민성, 강길선, 조한수, 송병주, 김혜린, 이동원, 김용기, 이영현
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| 소속 |
전북대 |
| 키워드 |
Valsartan; sustained-release; CMC; HPMC; direct compression
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| E-Mail |
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