| 학회 |
한국고분자학회 |
| 학술대회 |
2009년 가을 (10/08 ~ 10/09, 광주과학기술원 오룡관) |
| 권호 |
34권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Hybrid scaffold of porcine small intestinal submucosa and hyaluronic acidfor disc regeneration |
| 초록 |
The porcine small intestinal submucosa(SIS) without immunorejection responses and hyalunonic acid(HA) have been used as biomaterials. In this study, we dereloped novel scaffold that mixed SIS and HA(SIS-HA) for annulus fibrosus(AF). SIS-HA sponge was prepared by freeze-drying after addition 1 wt% HA solution in fabricatied SIS sponge. Sponge was crosslinked with 1-ethyl-(3-3-dimethyl aminopropyl) carbodiimide hydrochloride (EDC) solution with 100 mM concentration for 24 hrs and lyophilized. SIS-HA sponge was characterized by SEM and FT-IR to test their morphology and funcitional group. The ability of water absorption of sponge was evaluated. The presence of HA in SIS-HA sponge was demonstated by C-O funcitonal group. Moreover, we confirmed lower cytotoxicity and higher cell viability in the SIS-HA sponge than SIS. This may be due to the enhanced natural properties and higher water retention capacity of HA. This research was supported by MHWFA(0405-BO01-0204-0006) and WCU(R31-20029). |
| 저자 |
홍희경, 김순희, 이선경, 박현진, 최진희, 송이슬, 이종문, 이동원, 강길선
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| 소속 |
전북대 |
| 키워드 |
SIS; SIS-HA; AF; DISC
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| E-Mail |
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