| 학회 |
한국고분자학회 |
| 학술대회 |
2009년 봄 (04/09 ~ 04/10, 대전컨벤션센터) |
| 권호 |
34권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Preparation of Insulin-Loaded Microcapsules for Insulin Release |
| 초록 |
Insulin therapy is important in the treatment of patients with insulin-dependent diabetes mellitus (type 1) and for many patients with noninsulin-dependent diabetes mellitus (type 2). Patients with type 1 diabetes must self-administer insulin subcutaneously single or multiple times per day. These frequent injection have prompted research on alternative therapies. In this study, we prepared insulin-loaded microcapsules, consisting of an insulin core inside a PLGA shell. A solution containing these microcapsules could be easily injected by a microsurgical needle into type I diabetic rats. Sustained insulin release from these insulin-loaded microcapsules was observed, as well as longterm pharmacological duration of insulin activity, as shown by reduction of glycemia to normoglycemia. Moreover, the inflammatory response observed initially was reduced over time. Acknowledgements: This work was supported by KOSEF pioneer grant (M10711060001-08M1106-00110). |
| 저자 |
이주영1, 이상효2, 황성주3, 이해방1, 김문석1
|
| 소속 |
1한국화학(연), 2아주대, 3충남대 |
| 키워드 |
Insulin; microcapsule; transplantation; inflammation
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| E-Mail |
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