| 학회 |
한국고분자학회 |
| 학술대회 |
2009년 가을 (10/08 ~ 10/09, 광주과학기술원 오룡관) |
| 권호 |
34권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
The Osteogenic Differentiation in situ-forming Hydrogel for Rat Muscle derived Stem Cells |
| 초록 |
Chitosan is a natural and abundant polymer that is seen as an attractive candidate scaffolding material for tissue engineering. Also, Chitosan-based scaffolds have been shown to be biodegradable, nonimmunogenic and biocompatible. In this study, We formulated and characterized an in situforming chitosan gel consisting of chitosan and glycerol phosphate (GP) disodium salt, and examined the bone formation from rat muscle-derived stem cells (rMDSCs) using an injectable in situ-forming chitosan gel in vivo. First, The rMDSCs survived well on the scaffold created by the in vitro and in vivo in situ-forming chitosan gel. And bone formation was observed only in chitosan gel containing both rMDSCs and osteogenic factors. Subcutaneous implantation of the in situ-forming chitosan gel demonstrated that rMDSCs-containing chitosan gel induced much lower host tissue responses than did the chitosan gel alone, probably due to the immunosuppression of the transplanted rMDSCs. |
| 저자 |
이주영1, 강윤미2, 김이슬2, 황성주3, 이해방1, 김문석2
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| 소속 |
1한국화학(연), 2아주대, 3충남대 |
| 키워드 |
Rat muscle-derived stem cells; Osteogenic differentiation; Chitosan; In situ gel
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| E-Mail |
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