| 학회 |
한국고분자학회 |
| 학술대회 |
2002년 봄 (04/12 ~ 04/13, 서울대학교) |
| 권호 |
27권 1호, p.279 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Aqueous Nanoparticle Dispersion of Copolymer Derived from the p-dioxanone, L-lactide and Poly(ethylene glycol) as DNA Carrier |
| 초록 |
We have reported the nanoparticle dispersion of a hydrophobic/hydrophilic triblock copolymers consisting of poly(p-dioxanone)-co-poly(L-lactide) and Poly(ethylene glycol). The copolymer was synthesized and suspended in an aqueous medium from the acetonitrile solution to prepare its miceller particle. The micelle forming tendency of the copolymer was studied by the NMR technique and hydrophobic dye solublization method. Size of miceller particle was confirmed by dynamic light scattering method. Thus prepared aqueous nanoparticle dispersion was applied as non-viral vector for DNA carrier by transfection method on 3T3 cell. The nanoparticle dispersion was observed to be nontoxic for the cell growth and also facilitated the transfection.
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| 저자 |
Shanta Raj Bhattarai1, 김학용*2, 이호근**3, 황평한**4, 나라얀***
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| 소속 |
1전북대, 2*전북대, 3**전북대, 4***전북대 |
| 키워드 |
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| E-Mail |
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