| 초록 |
A lot of studies have been carried out to treat the alopecia via various approaches. In our group, to achieve the high treatment efficiency, hair follicle activation drugs were encapsulated in the biocompatible drug delivery system (DDS) to directly inject into the hair follicle. Firstly, liposome-based DDS was synthesized by using Dipalmitoyl phosphatidylcholine (DOPC) and Dioleoyl phosphatidylethanolamine (DOPE). Such monodispersed of carrier could be advantage to expand to the various application. In order to investigate the DDS for Alopecia treatment, the proper concentration of drug was encapsulated into the carrier and after treatment the activation of hair follicle-related genes were confirmed using the mouse hair follicle stem cells. Furthermore, the efficacy of alopecia treatment using the drug delivery system will be verified through cell differentiation efficiency and marker expression and in vivo experiments. |
