| 학회 |
한국화학공학회 |
| 학술대회 |
2016년 봄 (04/27 ~ 04/29, 부산 BEXCO) |
| 권호 |
22권 1호, p.471 |
| 발표분야 |
생물화공 |
| 제목 |
In Vitro Development of Specifically Binding RNA Aptamer to Endothelial Cell-Specific Molecule 1 (ESM-1) Protein for Early Detection of HCC |
| 초록 |
Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer with the highest incidence rates reported in East Asia. ESM-1 protein promote angiogenesis in HCC. For efficient HCC detection method, we use the aptamers. Aptamers are consist of single-stranded DNA or RNA and they can bind to various targets with high affinity and specificity. Aptamers have a number of advantages compare with antibody, stability at high temperature and pH conditions, and easy to application because easy modified with a various functional groups. For these reasons, we are used to RNA aptamers for ESM-1 protein detection and RNA aptamer selection with process called SELEX. This study was supported by Fund of Biomedical Research Institute, Chonbuk National University Hospital. (20120801002). This work was supported by the Human Resource Training Program for Regional Innovation and Creativity through the Ministry of Education and National Research Foundation of Korea (NRF-2015H1C1A1035921). |
| 저자 |
박대영1, 신우리1, 이경아1, 이은지1, Simranjeet Singh Sekhon1, 김대곤2, 안지영1, 민지호2, 김양훈1
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| 소속 |
1충북대, 2전북대 |
| 키워드 |
미생물공학; 효소/단백질공학; 생물공정공학
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| E-Mail |
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| 원문파일 |
초록 보기 |
