| 학회 |
한국고분자학회 |
| 학술대회 |
2017년 가을 (10/11 ~ 10/13, 제주컨벤션센터) |
| 권호 |
42권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 I |
| 제목 |
Transplantation of 3D-Printed Tracheal Graft Combined with iPS Cellsin Segmental Tracheal Defect Model |
| 초록 |
Here, we designed a artificial trachea which can enhance the regeneration of tracheal mucosa and cartilage through the optimal combination of 3D-printed scaffold and iPS-derived cells. Human bronchial epithelia cells (hBEC), iPS-mesenchymal stem cell (iPS-MSC) and iPS-chondrocytes (iPS-Chd) were used for regeneration of tracheal mucosa and cartilage in vivo. Each cells were seeded onto a surface of inner (hBEC) and outer layer (iPS-MSC or iPS-Chd) of scaffold. It was then transplanted in a segmental trachea defect. After 4 weeks postoperatively. Endoscopy did not reveal granulation ingrowth into tracheal lumen. Alcian blue staining clearly showed formation of ciliated epithelium in iPS-MSC groups. In addition, Micro-CT analysis proved that iPS-Chd groups were the most effective in forming neocartilage in defect sites. Therefore, this study provided a promising approach for the 3D reconstruction of a segment tracheal defect. |
| 저자 |
김인걸1, 권유욱1, 박수아2, 최지숙1, 조하나1, 권성근1
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| 소속 |
1서울대, 2한국기계(연) |
| 키워드 |
Trachea; Regeneration; Scaffold; iPSC
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| E-Mail |
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