| 초록 |
Poly(vinyl alcohol) (PVA) is frequently used for superselective embolization of vascular lesions. However, owing to irregularities of particle shape and size, inflammatory reaction in the wall of the embolized vascular tissue has a bad influence on the management. So regulation for particle-size homogeneity and spherical morphology should be required to some extent. In this study, to improve the durability of microspheres, syndiotacticity-rich PVA/poly(vinyl pivalate/vinyl acetate) (P(VPi/VAc)) microspheres with skin/core structure was prepared by heterogeneous saponification of P(VPi/VAc) microspheres. To prepare P(VPi/VAc) microspheres having various particle sizes and uniform particle size distributions, VPi and VAc were suspension-copolymerized, using a moderate-temperature initiator, 2,2'-azobis(2,4-dimethylvaleronitrile). Monodisperse P(VPi/VAc) particles with various particle diameters were obtained by controlling a low temperature suspension copolymerization conditions. Monodisperse P(VPi/VAc) microspheres were partially saponified in the heterogeneous system.
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