| 학회 |
한국공업화학회 |
| 학술대회 |
2015년 봄 (04/29 ~ 05/01, BEXCO (부산)) |
| 권호 |
19권 1호 |
| 발표분야 |
나노_포스터 |
| 제목 |
Graphene Oxide Optical Sensor for Detection of Acetylcholinesterase Activity and Its Inhibitor |
| 초록 |
Recently, it has been found that graphene oxide (GO) emits photostable and tunable fluorescence from a visible to a near infrared (NIR) range of electromagnetic spectrum. However, there are few reports for GO fluorescence-based biosensors. Here, we demonstrate a novel GO biosensor capable of assessing the activity of an enzyme, acetylcholinesterase (AChE), and detecting its inhibitor through its fluorescence change. To this end, GO was non-covalently functionalized by phenoxy-dextran polymer (GO-PhO-dex), which showed an outstanding colloidal stability and strong fluorescence in aqueous solution. GO-PhO-dex was able to report the hydrolysis activity of AChE through its turn-on fluorescence. In addition, GO-PhO-dex was capable of sensing an AChE inhibitor via its fluorescence quenching. |
| 저자 |
강태욱, 전수지, 김혜인, 임다빈, 박정현, 김종호
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| 소속 |
한양대 |
| 키워드 |
graphene oxide; optical detection; GO fluorescence; enzyme detection; inhibitor sensing
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| E-Mail |
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