| 학회 |
한국고분자학회 |
| 학술대회 |
2015년 가을 (10/06 ~ 10/08, 대구컨벤션센터(EXCO)) |
| 권호 |
40권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Magnetic Nanoparticle-Conjugated Polymeric Micelles for Combined Hyperthermia and Chemotherapy |
| 초록 |
Magnetic nanoparticles-conjugated polymeric micelles (MNPs-PMs) consisting of poly(ethylene glycol)-poly(lactide) (PEG-PLA) and iron oxide nanoparticles were prepared and used as nanocarriers for combined hyperthermia and chemotherapy. Doxorubicin was encapsulated in MNPs-PMs, and an alternating magnetic field (AMF) resulted in an increase to moderately increased temperature in a suitable range for inducing hyperthermia and a higher rate of drug release than observed without AMF. In vitro cytotoxicity and hyperthermia studies were carried out using human lung adenocarcinoma A549 cells. When MNPs-PMs encapsulated with an anticancer drug were used to treat A549 cells in combination with hyperthermia under AMF, the 78% of the cells were killed by the double effects of heat and the drug, and the combination was more effective than either chemotherapy or hyperthermia alone. Therefore, MNPs-PMs encapsulated with an anticancer drug show potential for combined chemotherapy and hyperthermia. |
| 저자 |
김현철, 이성준, 이세근, 정상원, 김은주, 하태린
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| 소속 |
대구경북과학기술원 |
| 키워드 |
magnetic nanoparticle; polymeric micelle; drug delivery system; chemotherapy; hyperthermia
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| E-Mail |
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